2. Academic Validation
  3. Synthesis and cytotoxic activity of 17-carboxylic acid modified 23-hydroxy betulinic acid ester derivatives

Synthesis and cytotoxic activity of 17-carboxylic acid modified 23-hydroxy betulinic acid ester derivatives

  • Bioorg Med Chem Lett. 2007 Mar 1;17(5):1475-8. doi: 10.1016/j.bmcl.2006.09.096.
Yi Bi 1,  Jinyi Xu,  Xiaoming Wu,  Wencai Ye,  Shengtao Yuan,  Luyong Zhang
Affiliations

Affiliation

  • 1 Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
PMID: 17275295 DOI: 10.1016/j.bmcl.2006.09.096
Abstract

New 17-carboxylic acid modified 23-hydroxy betulinic acid ester derivatives were prepared and tested for cytotoxic activity on five Cancer cell lines in vitro: all tested compounds showed stronger cytotoxic activity than 23-hydroxy betulinic acid and betulinic acid. In addition, compound 5a was tested for anti-tumor activity in vivo: it had much better anti-tumor activity than 23-OH betulinic acid and had similar anti-tumor activity with cyclophosphamide and 5-fluorouracil.

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