2. Academic Validation
  3. Hypoxia-inducible factor-1 and nuclear factor-kappaB inhibitory meroterpene analogues of bakuchiol, a constituent of the seeds of Psoralea corylifolia

Hypoxia-inducible factor-1 and nuclear factor-kappaB inhibitory meroterpene analogues of bakuchiol, a constituent of the seeds of Psoralea corylifolia

  • Bioorg Med Chem Lett. 2008 Apr 15;18(8):2619-23. doi: 10.1016/j.bmcl.2008.03.028.
Cheng-Zhu Wu 1,  Seong Su Hong,  Xing Fu Cai,  Nguyen Tien Dat,  Ji-Xing Nan,  Bang Yeon Hwang,  Jung Joon Lee,  Dongho Lee
Affiliations

Affiliation

  • 1 Molecular Cancer Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-806, Republic of Korea.
PMID: 18359631 DOI: 10.1016/j.bmcl.2008.03.028
Abstract

Two new meroterpenoids, 12,13-dihydro-12,13-dihydroxybakuchiol (2) and (12'S)-bisbakuchiol C (3), were isolated from the seeds of Psoralea corylifolia L. (Fabaceae). The structures of 2 and 3 were elucidated by spectroscopic and chemical methods. Six meroterpenoids isolated from P. corylifolia and three semi-synthetic analogues were evaluated for HIF-1 and NF-kappaB inhibition, and O-methyl and O-ethylbakuchiols (6 and 7) inhibited HIF-1 and NF-kappaB activation without significantly decreasing the viability of the AGS and HeLa cells, respectively.

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