1. Academic Validation
  2. Isolation of two toxic heptapeptide microcystins from an axenic strain of Microcystis aeruginosa, K-139

Isolation of two toxic heptapeptide microcystins from an axenic strain of Microcystis aeruginosa, K-139

  • Toxicon. 1991;29(4-5):479-89. doi: 10.1016/0041-0101(91)90022-j.
K Harada 1 K Ogawa K Matsuura H Nagai H Murata M Suzuki Y Itezono N Nakayama M Shirai M Nakano
Affiliations

Affiliation

  • 1 Faculty of Pharmacy, Meijo University, Nagoya, Japan.
Abstract

Two toxic heptapeptides were isolated from an axenic Microcystis aeruginosa strain, K-139. Using mainly a non-destructive NMR method, we determined the structure of the major toxin to be 7-desmethylmicrocystin LR which lacks an N-methyl group of the dehydroalanine moiety of microcystin LR. The minor toxin was deduced to be 3,7-didesmethylmicrocystin LR. The chromatographic and NMR analyses of 7-desmethylmicrocystin LR were compared with those of 3-desmethylmicrocystin LR.

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