2. Academic Validation
  3. In vitro anti-inflammatory activity of lignans isolated from Magnolia fargesii

In vitro anti-inflammatory activity of lignans isolated from Magnolia fargesii

  • Bioorg Med Chem Lett. 2009 Feb 1;19(3):937-40. doi: 10.1016/j.bmcl.2008.11.103.
Jae Yeon Kim 1,  Hyo Jin Lim,  Da Yeon Lee,  Ji Sun Kim,  Do Hee Kim,  Hwa Jin Lee,  Hee Doo Kim,  Raok Jeon,  Jae-Ha Ryu
Affiliations

Affiliation

  • 1 College of Pharmacy, Sookmyung Women's University, 52 Hyochangwon-Gil, Yongsan-Gu, Seoul 140-742, Republic of Korea.
PMID: 19110419 DOI: 10.1016/j.bmcl.2008.11.103
Abstract

The overproduction of nitric oxide (NO) and prostaglandin E(2) (PGE(2)) causes neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. Four Lignans, (+)-eudesmin (1), (+)-magnolin (2), (+)-yangambin (3) and a new structure named as epimagnolin B (4) were isolated from Magnolia fargesii (Magnoliaceae) as the inhibitors of NO production in LPS-activated microglia. The most potent compound 4 inhibited the production of NO and PGE(2) and the expression of respective Enzyme iNOS and COX-2 through the suppression of I-kappaB-alpha degradation and nuclear translocation of p65 subunit of NF-kappaB.

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