2. Academic Validation
  3. Oleanane-type triterpenoids from Aceriphyllum rossii and their cytotoxic activity

Oleanane-type triterpenoids from Aceriphyllum rossii and their cytotoxic activity

  • J Nat Prod. 2009 Aug;72(8):1419-23. doi: 10.1021/np900273z.
Le Thi Kim Van 1,  Tran Manh Hung,  Phuong Thien Thuong,  Tran Minh Ngoc,  Jin Cheol Kim,  Han-Su Jang,  Xing Fu Cai,  Sei Ryang Oh,  Byung-Sun Min,  Mi Hee Woo,  Jae Sue Choi,  Hyeong Kyu Lee,  Kihwan Bea
Affiliations

Affiliation

  • 1 College of Pharmacy, Catholic University of Daegu, Gyeongsan 712-702, Korea.
PMID: 19618898 DOI: 10.1021/np900273z
Abstract

The hexane-soluble fraction of the roots of Aceriphyllum rossii was used to isolate seven new oleanane-type triterpenoids, aceriphyllic acids C-I (1-7), together with seven known triterpenoids. The structures of aceriphyllic acids C-I were determined as 3alpha-hydroxyolean-12-en-23,29-dioic acid (1), 3beta-hydroxyolean-12-en-23,29-dioic acid (2), 3beta,23-dihydroxyolean-12-en-29-oic acid (3), 3alpha-O-acetylolean-12-en-23,27-dioic acid (4), 3alpha-O-caffeoylolean-12-en-27-oic acid (5), 3alpha-O-acetylolean-12-en-23,29-dioic acid (6), and 3alpha-hydroxyolean-12-en-23-al-27-oic acid (7) by spectroscopic analyses. In the evaluation of the in vitro cytotoxicity of these compounds against the MCF-7 and LLC Cancer cell lines, compounds 10 and 13 exhibited cytotoxic activity against the LLC Cancer cell line with IC(50) values of 7.63 and 6.56 microM, respectively.

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