2. Academic Validation
  3. Synthesis and investigation of inhibition effect of fluorinated sulfonamide derivatives on carbonic anhydrase

Synthesis and investigation of inhibition effect of fluorinated sulfonamide derivatives on carbonic anhydrase

  • Eur J Med Chem. 2010 Mar;45(3):1225-9. doi: 10.1016/j.ejmech.2009.11.052.
Zohra Benfodda 1,  Franck Guillen,  Bernard Romestand,  Abdelkader Dahmani,  Hubert Blancou
Affiliations

Affiliation

  • 1 Institut des Biomolécules Max Mousseron UMR CNRS 5247 Université de Montpellier I et de Montpellier II, CC1706, Place Eugène Bataillon 34095 Montpellier cedex 05, France.
PMID: 20036446 DOI: 10.1016/j.ejmech.2009.11.052
Abstract

Series of perfluoroalkanesulfonamides 1, sodium salt of perfluoroalkanesulfonamides 2 and polyfluoroalkanesulfonamides 3 derivatives were synthesized and characterized by (1)H NMR, (13)C NMR, (19)F NMR, IR and HRMS. Inhibition effects of these compounds on bovine Carbonic Anhydrase (bCA) and human Carbonic Anhydrase isoenzyme II (hCA) have been investigated. Comparing IC(50) values of the synthesized molecules 1, 2 and 3, it has been found that compound 2b is a more potent inhibitor than acetazolamide on hCA. Moreover 2b does not present cellular toxicity on sheep red globules.

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