2. Academic Validation
  3. Chemoenzymatic synthesis of rivastigmine via dynamic kinetic resolution as a key step

Chemoenzymatic synthesis of rivastigmine via dynamic kinetic resolution as a key step

  • J Org Chem. 2010 May 7;75(9):3105-8. doi: 10.1021/jo9027374.
Kiwon Han 1,  Cheolwoo Kim,  Jaiwook Park,  Mahn-Joo Kim
Affiliations

Affiliation

  • 1 Department of Chemistry and Bionanotechnology Center, Pohang University of Science and Technology, San-31 Hyojadong, Pohang 790-784, Korea.
PMID: 20345141 DOI: 10.1021/jo9027374
Abstract

A practical and efficient procedure for the synthesis of rivastigmine was developed. This procedure includes dynamic kinetic resolution using a polymer-bound ruthenium complex and a Lipase in combination as a key step. Enantiopure (-)-rivastigmine was obtained from commercially available 3'-hydroxyacetophenone via five steps in overall 57% yield.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z