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  3. New diterpenoids from Caesalpinia species and their cytotoxic activity

New diterpenoids from Caesalpinia species and their cytotoxic activity

  • Bioorg Med Chem Lett. 2010 May 1;20(9):2847-50. doi: 10.1016/j.bmcl.2010.03.048.
Biswanath Das 1,  Yallamalla Srinivas,  Chithaluri Sudhakar,  Ibram Mahender,  Keetha Laxminarayana,  Parigi Raghavendar Reddy,  Tuniki Venugopal Raju,  Naga Mahesh Jakka,  Janapala Venkateswara Rao
Affiliations

Affiliation

  • 1 Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad 500 007, India. biswanathdas@yahoo.com
PMID: 20356735 DOI: 10.1016/j.bmcl.2010.03.048
Abstract

Chemical investigation on Caesalpinia crista afforded two new Diterpenoids, 6beta-cinnamoyloxy-7beta-acetoxyvouacapen-5alpha-ol and 6beta,7beta-dibenzoyloxyvouacapen-5alpha-ol and on Caesalpiniapulcherrima another new diterpenoid, 12-demethyl neocaesalpin F along with several known constituents. The structures of the new compounds were settled from their 1D and 2D NMR spectral data. The cytotoxicity of these compounds was measured on two different Cancer cell lines.

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