2. Academic Validation
  3. Synthesis, antiproliferative activity and inhibition of tubulin polymerization by anthracenone-based oxime derivatives

Synthesis, antiproliferative activity and inhibition of tubulin polymerization by anthracenone-based oxime derivatives

  • Eur J Med Chem. 2010 Aug;45(8):3354-64. doi: 10.1016/j.ejmech.2010.04.019.
Georg Surkau 1,  Konrad J Böhm,  Klaus Müller,  Helge Prinz
Affiliations

Affiliation

  • 1 Institute of Pharmaceutical and Medicinal Chemistry, Westphalian Wilhelms-University, Hittorfstrasse 58-62, D-48149 Münster, Germany.
PMID: 20546980 DOI: 10.1016/j.ejmech.2010.04.019
Abstract

A series of anthracenone-based oxime ethers and -esters were synthesized in order to evaluate their antiproliferative activity. Several investigated compounds displayed strong antiproliferative activity against K562 leukemia cells and proved to be strong inhibitors of tubulin polymerization. In this context, anthracenone-based oxime ethers and -esters are considered to contribute to the development of novel antiproliferative drugs, based on tubulin interaction.

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