2. Academic Validation
  3. Re-exploration of the PHCCC Scaffold: Discovery of Improved Positive Allosteric Modulators of mGluR4

Re-exploration of the PHCCC Scaffold: Discovery of Improved Positive Allosteric Modulators of mGluR4

  • ACS Chem Neurosci. 2010 Jun 16;1(6):411-419. doi: 10.1021/cn9000318.
Richard Williams 1,  Ya Zhou,  Colleen M Niswender,  Qingwei Luo,  P Jeffrey Conn,  Craig W Lindsley,  Corey R Hopkins
Affiliations

Affiliation

  • 1 Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
PMID: 20582156 DOI: 10.1021/cn9000318
Abstract

This Letter describes a detailed SAR analysis of the mGluR4 positive allosteric modulator, PHCCC. We have now developed compounds with improved potency and efficacy; in addition, compounds are presented that show selectivity for mGluR4 versus the other mGluR subtypes.

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