2. Academic Validation
  3. Regioselective synthesis of di-C-glycosylflavones possessing anti-inflammation activities

Regioselective synthesis of di-C-glycosylflavones possessing anti-inflammation activities

  • Org Biomol Chem. 2010 Oct 7;8(19):4451-62. doi: 10.1039/c0ob00011f.
Jiun-Jie Shie 1,  Chih-An Chen,  Chih-Chien Lin,  Angela Fay Ku,  Ting-Jen R Cheng,  Jim-Min Fang,  Chi-Huey Wong
Affiliations

Affiliation

  • 1 The Genomics Research Center, Academia Sinica, Taipei, 115, Taiwan.
PMID: 20725659 DOI: 10.1039/c0ob00011f
Abstract

Three methods are utilized to synthesize a variety of 6,8-di-C-glycosylflavones bearing identical or distinct glycosyl moieties. Some C-glycosylation compounds are found to have better anti-inflammation activities than the parent Flavones. Among them, 6,8-di-C-glucosylapigenin (known as vicenin-2) shows inhibition of TNF-alpha expression and NO production with IC(50) values of 6.8 and 5.2 muM, respectively.

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