2. Academic Validation
  3. Tyrphostin analogs are GPR35 agonists

Tyrphostin analogs are GPR35 agonists

  • FEBS Lett. 2011 Jun 23;585(12):1957-62. doi: 10.1016/j.febslet.2011.05.026.
Huayun Deng 1,  Haibei Hu,  Ye Fang
Affiliations

Affiliation

  • 1 Biochemical Technologies, Science and Technology Division, Corning Inc., Corning, NY 14831, United States.
PMID: 21601572 DOI: 10.1016/j.febslet.2011.05.026
Abstract

GPR35 is an orphan G protein-coupled receptor that is not well-characterized. Here we employ dynamic mass redistribution (DMR) assays to discover new GPR35 agonists. DMR assays identified tyrphostin analogs as GPR35 agonists, which were confirmed with receptor internalization, Tango β-arrestin translocation, and extracellular-signal-regulated kinase phosphorylation assays. These agonists provide pharmacological tools to study the biology and function of GPR35.

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