1. Academic Validation
  2. Cutting-edge technologies in colon-targeted drug delivery systems

Cutting-edge technologies in colon-targeted drug delivery systems

  • Expert Opin Drug Deliv. 2011 Oct;8(10):1247-58. doi: 10.1517/17425247.2011.597739.
Mayur M Patel
Abstract

Oral colon-targeted Drug Delivery systems have gained enormous attention among researchers in the last two decades. The significance of this site-specific Drug Delivery system can be measured by its usefulness for delivering a variety of therapeutic agents, both for the treatment of local diseases or for systemic therapies. With the arrival of newer innovations, a large number of breakthrough technologies have emerged for targeting a drug molecule to the colon. Researchers have attempted various approaches in the development of these formulation technologies, such as pH-dependent, time-dependent and microflora-activated systems. Recently, a number of approaches have been proposed that utilize a novel concept of di-dependent Drug Delivery systems, that is, the systems in which the drug release is controlled by two factors: pH and time, and pH and microflora of the colon. This Editorial article is not intended to offer a comprehensive review on Drug Delivery, but shall familiarize the readers with the formulation technologies that have been developed for attaining colon-specific Drug Delivery.

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