2. Academic Validation
  3. Novel poly(ADP-ribose) polymerase-1 inhibitors

Novel poly(ADP-ribose) polymerase-1 inhibitors

  • Bioorg Med Chem Lett. 2012 Jan 1;22(1):222-4. doi: 10.1016/j.bmcl.2011.11.032.
Derek Dunn 1,  Jean Husten,  Mark A Ator,  Sankar Chatterjee
Affiliations

Affiliation

  • 1 Cephalon, Inc., 145 Brandywine Parkway, West Chester, PA 19380 4245, USA.
PMID: 22153339 DOI: 10.1016/j.bmcl.2011.11.032
Abstract

Synthesis and activity of a series of 3-aroyl-derived analogs of novel pyrrolocarbazole 1 as poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors are disclosed.

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