2. Academic Validation
  3. JBIR-94 and JBIR-125, antioxidative phenolic compounds from Streptomyces sp. R56-07

JBIR-94 and JBIR-125, antioxidative phenolic compounds from Streptomyces sp. R56-07

  • J Nat Prod. 2012 Jan 27;75(1):107-10. doi: 10.1021/np200734p.
Teppei Kawahara 1,  Miho Izumikawa,  Misa Otoguro,  Hideki Yamamura,  Masayuki Hayakawa,  Motoki Takagi,  Kazuo Shin-ya
Affiliations

Affiliation

  • 1 Biomedicinal Information Research Center, Japan Biological Informatics Consortium, 2-4-7 Aomi, Koto-ku, Tokyo 135-0064, Japan.
PMID: 22233425 DOI: 10.1021/np200734p
Abstract

Two phenolic compounds, JBIR-94 (1) and JBIR-125 (2), were isolated from the fermentation broth of strain R56-07, which was identified by phylogenetic methods as a novel species of Streptomyces. The structures of 1 and 2 were assigned on the basis of 1D and 2D NMR spectroscopy and MS analyses. Compounds 1 and 2 exhibited 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity with an IC(50) value of 11.4 and 35.1 μM, respectively. These compounds are the first examples of hydroxycinnamic acid amides containing putrescine or spermidine produced by actinomycetes.

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    Product Name
    Description
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    Research Area
  • HY-N12897
    酚类化合物
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