2. Academic Validation
  3. Identification of hydrophobic tags for the degradation of stabilized proteins

Identification of hydrophobic tags for the degradation of stabilized proteins

  • Chembiochem. 2012 Mar 5;13(4):538-41. doi: 10.1002/cbic.201100793.
Hyun Seop Tae 1,  Thomas B Sundberg,  Taavi K Neklesa,  Devin J Noblin,  Jeffrey L Gustafson,  Anke G Roth,  Kanak Raina,  Craig M Crews
Affiliations

Affiliation

  • 1 Department of Molecular Cellular and Developmental Biology, Yale University, 219 Prospect Street, New Haven, CT 06511, USA.
PMID: 22271667 DOI: 10.1002/cbic.201100793
Abstract

New HyTs are a knockout: we previously reported that labeling HaloTag proteins with low molecular weight hydrophobic tags (HyTs) leads to targeted degradation of HaloTag fusion proteins. In this report, we employed a chemical approach to extend this hydrophobic tagging methodology to highly stabilized proteins by synthesizing and evaluating a library of HyTs, which led to the identification of HyT36.

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  • HY-141676
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