2. Academic Validation
  3. Three triterpenoid saponins from the roots of Polygala japonica Houtt

Three triterpenoid saponins from the roots of Polygala japonica Houtt

  • Fitoterapia. 2012 Oct;83(7):1184-90. doi: 10.1016/j.fitote.2012.07.002.
Chuangjun Li 1,  Jing Fu,  Jingzhi Yang,  Dongming Zhang,  Yuhe Yuan,  Naihong Chen
Affiliations

Affiliation

  • 1 State Key Laboratory of Bioactive Substance and Function of NaturalMedicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, PR China.
PMID: 22796402 DOI: 10.1016/j.fitote.2012.07.002
Abstract

Three new triterpenoid saponins polygalasaponins LI-LIII (1-3) with two acylation groups in oligosaccharide chain, together with three known saponins were isolated from the roots of Polygala japonica Houtt. (4-6). The neuroprotective effects of these compounds on neuron-like PC12 cells were evaluated in vitro. Compounds 5 and 6 show neuroprotective effects in Aβ₂₅₋₃₅ model at the concentration of 10 μM.

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