2. Academic Validation
  3. Effect of oxindole alkaloids from the hooks of Uncaria macrophylla on thiopental-induced hypnosis

Effect of oxindole alkaloids from the hooks of Uncaria macrophylla on thiopental-induced hypnosis

  • Phytomedicine. 1998 Apr;5(2):83-6. doi: 10.1016/S0944-7113(98)80002-0.
I Sakakibara 1,  H Takahashi,  S Terabayashi,  M Yuzurihara,  M Kubo,  A Ishige,  M Higuchi,  Y Komatsu,  M Okada,  M Maruno,  C Biqiang,  H X Jiang
Affiliations

Affiliation

  • 1 Tsumura Central Research Laboratories, Amimachi, Inashikigun, Ibaraki, Japan.
PMID: 23195758 DOI: 10.1016/S0944-7113(98)80002-0
Abstract

Four tetracyclic oxindole Alkaloids, rhynchophylline, isorhynchophylline, corynoxine and corynoxine B were isolated from the hooks of Uncaria macrophylla Wall. (Rubiaceae), that is a dominant plant widely distributed in Yunnan province. These compounds exhibited prolongation of the thiopental-induced hypnosis on oral administration in mice.

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