2. Academic Validation
  3. Lanostane triterpenes from cultures of the Basidiomycete Ganoderma orbiforme BCC 22324

Lanostane triterpenes from cultures of the Basidiomycete Ganoderma orbiforme BCC 22324

  • Phytochemistry. 2013 Mar;87:133-9. doi: 10.1016/j.phytochem.2012.11.022.
Masahiko Isaka 1,  Panida Chinthanom,  Surisa Kongthong,  Kitlada Srichomthong,  Rattaket Choeyklin
Affiliations

Affiliation

  • 1 National Center for Genetic Engineering and Biotechnology (BIOTEC), Klong Luang, Pathumthani 12120, Thailand. isaka@biotec.or.th
PMID: 23280041 DOI: 10.1016/j.phytochem.2012.11.022
Abstract

Seven lanostane triterpenoids, ganorbiformins A-G, together with twelve known compounds, were isolated from cultures of the mushroom fungus Ganoderma orbiforme BCC 22324. Ganorbiformin A is an unusual rearranged analog, whereas the other compounds share the same lanostane skeleton with known ganoderic acids. The C-3 epimer of ganoderic acid T also exhibited significant antimycobacterial activity against Mycobacterium tuberculosis H37Ra (MIC 1.3 μM).

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