2. Academic Validation
  3. An efficient Au-catalyzed synthesis of isomukonidine, clausine L, mukonidine, glycosinine, mukonal, and clausine V from propadienyl methyl ether

An efficient Au-catalyzed synthesis of isomukonidine, clausine L, mukonidine, glycosinine, mukonal, and clausine V from propadienyl methyl ether

  • Org Biomol Chem. 2013 Feb 13;11(10):1666-71. doi: 10.1039/c2ob27432a.
Youai Qiu 1,  Dengke Ma,  Chunling Fu,  Shengming Ma
Affiliations

Affiliation

  • 1 Laboratory of Molecular Recognition and Synthesis, Department of Chemistry, Zhejiang University, Hangzhou 310027, People's Republic of China.
PMID: 23358535 DOI: 10.1039/c2ob27432a
Abstract

Naturally occurring Carbazole Alkaloids such as isomukonidine, clausine L, mukonidine, glycosinine, mukonal, and clausine V have been synthesized through a gold-catalyzed cyclization reaction of 1-(indol-2-yl)-2-methoxy-2,3-allenols, which are readily available from indolecarbaldehydes and methoxypropadiene. Compared to the reported procedures, our approach is general, atom economic, highly selective, and the starting Materials are easily available.

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