2. Academic Validation
  3. Antifilarial activity of CGP 20376 against subperiodic Brugia malayi in the leaf-monkey Presbytis cristata

Antifilarial activity of CGP 20376 against subperiodic Brugia malayi in the leaf-monkey Presbytis cristata

  • Trop Med Parasitol. 1990 Mar;41(1):10-2.
J W Mak 1,  K Suresh,  P L Lam,  M F Choong,  H P Striebel
Affiliations

Affiliation

  • 1 Institute for Medical Research, Kuala Lumpur, Malaysia.
PMID: 2339241
Abstract

CGP 20376, a 5-methoxyl-6-dithiocarbamic-S- (2-carboxy-ethyl) ester derivative of benzothiazole was evaluated for its antifilarial properties and shown to be extremely effective against subperiodic Brugia malayi in the leaf-monkey, Presbytis cristata at oral doses of 20-100 mg/kg. The compound and/or its metabolites had complete micro- and microfilaricidal activities even when given at a single dose of 20 mg/kg. Lower doses had incomplete filaricidal action.

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