2. Academic Validation
  3. Synthesis and biological activity of novel series of 1,3-benzoxazol-2(3H)-one derivatives

Synthesis and biological activity of novel series of 1,3-benzoxazol-2(3H)-one derivatives

  • Acta Pol Pharm. 2013 Mar-Apr;70(2):245-53.
Mariola Krawiecka 1,  Bozena Kuran,  Jerzy Kossakowski,  Marta Kierzkowska,  Grazyna Młynarczyk,  Marcin Cieślak,  Julia Kaźmierczak-Barańska,  Karolina Królewska,  Michał A Dobrowolski
Affiliations

Affiliation

  • 1 Department of Medical Chemistry, Medical University of Warsaw, 3 Oczki St., 02-007 Warszawa, Poland.
PMID: 23614280
Abstract

In the search for novel biological agents, a series of new derivatives N-substituted 1,3-benzoxazol-2(3H)-one, 5-chloro-1,3-benzoxazol-2(3H)-one, 6-bromo-1,3-benzoxazol-2(3H)-one were prepared. All of the compounds were characterized by 1H NMR, 13C NMR and ESI MS spectra. Moreover, for compound 1 an Xray structure was determined. All derivatives were tested for antimicrobial activity against a selection of Gram-positive, Gram-negative bacteria and yeasts. The selected compounds (2-8, 10) were tested for their cytotoxic properties in K562, HeLa and normal cells.

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