2. Academic Validation
  3. Dihydroartemisinin induces autophagy by suppressing NF-κB activation

Dihydroartemisinin induces autophagy by suppressing NF-κB activation

  • Cancer Lett. 2014 Feb 28;343(2):239-48. doi: 10.1016/j.canlet.2013.09.035.
Wei Hu 1,  Sang-Sang Chen 1,  Jia-Li Zhang 1,  Xiao-E Lou 1,  Hui-Jun Zhou 2
Affiliations

Affiliations

  • 1 Institute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, People's Republic of China.
  • 2 Institute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, People's Republic of China. Electronic address: zhouhj_zhouhj@yahoo.com.
PMID: 24099910 DOI: 10.1016/j.canlet.2013.09.035
Abstract

Nuclear factor-kappa B (NF-κB) and Autophagy are two major regulators involved in both tumor initiation and progression. However, the association between these two signaling pathways still remains obscure. In this work, we demonstrate that dihydroartemisinin (DHA) stimulates the induction of Autophagy in several Cancer cell lines through repression of NF-κB activity. We also show that inhibiting NF-κB results in an accumulation of Reactive Oxygen Species (ROS), which participate in the stimulation of Autophagy. These findings present a pathway by which DHA promotes Autophagy in Cancer cells and provide evidence for the DHA-induced sensitization effect of some chemotherapeutics.

Keywords

4-Hydroxy-TEMPO; AO; AVOs; Autophagy; CQ; Chloroquine; DHA; DHE; Dihydroartemisinin; FHC; IκB; MnSOD; NF-κB; ROS; TNF-α; Tempo; Translocation; acidic vesicular organelles; acridine orange; dihydroartemisinin; dihydroethidium; ferritin heavy chain; inhibitory subunit of NF-κB; manganese superoxide dismutase; nuclear factor-kappa B; reactive oxygen species; tumor necrosis factor-α.

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