2. Academic Validation
  3. Antimicrobial activity of de novo designed cationic peptides against multi-resistant clinical isolates

Antimicrobial activity of de novo designed cationic peptides against multi-resistant clinical isolates

  • Eur J Med Chem. 2014 Jan;71:31-5. doi: 10.1016/j.ejmech.2013.10.065.
Diego Faccone 1,  Omar Veliz 1,  Alejandra Corso 1,  Martin Noguera 2,  Melina Martínez 3,  Cristian Payes 4,  Liliana Semorile 3,  Paulo Cesar Maffía 5
Affiliations

Affiliations

  • 1 Servicio Antimicrobianos, Instituto Nacional de Enfermedades Infecciosas (INEI)-ANLIS "Dr. Carlos G. Malbran", Buenos Aires, Argentina.
  • 2 Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina.
  • 3 Laboratorio de Microbiología Molecular, Universidad Nacional de Quilmes, Buenos Aires, Argentina.
  • 4 Laboratorio de Microbiología Molecular, Universidad Nacional de Quilmes, Buenos Aires, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina.
  • 5 Laboratorio de Microbiología Molecular, Universidad Nacional de Quilmes, Buenos Aires, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina. Electronic address: pcmaffia@hotmail.com.
PMID: 24269514 DOI: 10.1016/j.ejmech.2013.10.065
Abstract

Antibiotic resistance is one of the main problems concerning public health or clinical practice. Antimicrobial Peptides appear as good candidates for the development of new therapeutic drugs. In this study we de novo designed a group of cationic Antimicrobial Peptides, analyzed its physicochemical properties, including its structure by circular dichroism and studied its antimicrobial properties against a panel of clinical isolates expressing different mechanisms of resistance. Three cationic alpha helical Peptides exhibited antimicrobial activity comparable to, or even better than the comparator omiganan (MBI-226).

Keywords

Antimicrobial; Cationic; Peptides; Resistance.

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