Quinolone alkaloids from Fructus Euodiae show activity against methicillin-resistant Staphylococcus aureus

Fructus Euodiae is used in traditional Chinese medicine to treat Infection. In this study, four of the quinolone Alkaloids isolated from Fructus Euodiae showed activity against methicillin-resistant Staphylococcus aureus (MRSA). The minimum inhibitory concentrations (MIC) were 8-128 µg/mL, which were equivalent to or lower than the control Antibiotics, oxacillin, erythromycin and Tetracycline (MIC ≥128 µg/mL). Among these isolated quinolone Alkaloids, evocarpine with a 13 carbon alkenyl chain substituent at position-2 showed the best activity against MRSA. This study has demonstrated the potential of quinolone Alkaloids from Fructus Euodiae as anti-MRSA compounds and supports the traditional use of the fruit as a treatment for Bacterial infections.

Evocarpine; MIC; MRSA; antibacterial; minimum inhibitory concentration.