2. Academic Validation
  3. New phenyl derivatives from endophytic fungus Aspergillus flavipes AIL8 derived of mangrove plant Acanthus ilicifolius

New phenyl derivatives from endophytic fungus Aspergillus flavipes AIL8 derived of mangrove plant Acanthus ilicifolius

  • Fitoterapia. 2014 Jun:95:194-202. doi: 10.1016/j.fitote.2014.03.021.
Zhi-Qiang Bai 1,  Xiuping Lin 2,  Yizhu Wang 3,  Junfeng Wang 2,  Xuefeng Zhou 2,  Bin Yang 2,  Juan Liu 2,  Xianwen Yang 2,  Yi Wang 4,  Yonghong Liu 5
Affiliations

Affiliations

  • 1 CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China; Key Laboratory of Marine Materia Medica/RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China; Guangdong Institute of Microbiology, Guangzhou 510070, China.
  • 2 CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China; Key Laboratory of Marine Materia Medica/RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China.
  • 3 Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing 100700, China; Department of Genetics, School of Basic Medical Sciences, Jilin University, Changchun 130021, China.
  • 4 Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing 100700, China.
  • 5 CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China; Key Laboratory of Marine Materia Medica/RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China. Electronic address: yonghongliu@scsio.ac.cn.
PMID: 24704337 DOI: 10.1016/j.fitote.2014.03.021
Abstract

Two new aromatic butyrolactones, flavipesins A (1) and B (2), two new Natural Products (3 and 4), and a known phenyl dioxolanone (5) were isolated from marine-derived endophytic fungus Aspergillus flavipes. The structures of compounds 1-5 were elucidated by 1D- and 2D-NMR and MS analysis, the absolute configurations were assigned by optical rotation and CD data, and the stereochemistry of 1 was determined by X-ray crystallography analysis. 1 demonstrated lower MIC values against Staphylococcus aureus (8.0 μg/mL) and Bacillus subtillis (0.25 μg/mL). 1 also showed the unique antibiofilm activity of penetration through the biofilm matrix and kills live bacteria inside mature S. aureus biofilm.

Keywords

Acanthus ilicifolius; Aspergillus flavipes; Butyrolactones; Endophytic fungus; Mangrove plant.

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