2. Academic Validation
  3. Calphostins (UCN-1028), novel and specific inhibitors of protein kinase C. I. Fermentation, isolation, physico-chemical properties and biological activities

Calphostins (UCN-1028), novel and specific inhibitors of protein kinase C. I. Fermentation, isolation, physico-chemical properties and biological activities

  • J Antibiot (Tokyo). 1989 Oct;42(10):1470-4. doi: 10.7164/antibiotics.42.1470.
E Kobayashi 1,  K Ando,  H Nakano,  T Iida,  H Ohno,  M Morimoto,  T Tamaoki
Affiliations

Affiliation

  • 1 Tokyo Research Laboratory, Kyowa Hakko Kogyo Co., Ltd., Tokyo, Japan.
PMID: 2478514 DOI: 10.7164/antibiotics.42.1470
Abstract

A novel complex of calphostin (UCN-1028), which specifically inhibits protein kinase C (PKC) has been isolated from the culture broth of a fungi Cladosporium cladosporioides. Purification of individual components was carried out by silica gel, non-porus resin Diaion HP-20SS and Sephadex LH-20 chromatography, leading to isolation of five closely related components. A, B, C, D and I. Calphostins showed cytotoxic activities against various tumor cells, and these cytotoxicities were proportional to their inhibitory activities against PKC.

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