2. Academic Validation
  3. Anti-tumor properties of orally administered glucosamine and N-acetyl-D-glucosamine oligomers in a mouse model

Anti-tumor properties of orally administered glucosamine and N-acetyl-D-glucosamine oligomers in a mouse model

  • Carbohydr Polym. 2014 Oct 13:111:783-7. doi: 10.1016/j.carbpol.2014.04.102.
Sachie Masuda 1,  Kazuo Azuma 2,  Seiji Kurozumi 1,  Masatoshi Kiyose 1,  Tomohiro Osaki 1,  Takeshi Tsuka 1,  Norihiko Itoh 1,  Tomohiro Imagawa 1,  Saburo Minami 1,  Kimihiko Sato 3,  Yoshiharu Okamoto 4
Affiliations

Affiliations

  • 1 Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Tottori University, 4-101 Koyama-minami, Tottori 680-8553, Japan.
  • 2 Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Tottori University, 4-101 Koyama-minami, Tottori 680-8553, Japan. Electronic address: kazu-azuma@mues.tottori-u.ac.jp.
  • 3 Koyo Chemical Co. Ltd., 3-11-15 Iidabashi, Chiyodaku, Tokyo 102-0072, Japan.
  • 4 Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Tottori University, 4-101 Koyama-minami, Tottori 680-8553, Japan. Electronic address: yokamoto@muses.tottori-u.ac.jp.
PMID: 25037416 DOI: 10.1016/j.carbpol.2014.04.102
Abstract

The current study evaluated the anti-tumor activities of N-acetyl-d-glucosamine oligomer (NACOS) and glucosamine oligomer (COS) after their oral administration in a tumor (colon 26)-bearing mouse model. Compared to the control group, NACOS and COS groups showed significantly suppressed tumor growth, and apparent, marked Apoptosis in tumor tissues. Furthermore, serum interleukin-12p70 and interferon-γ levels significantly increased in the NACOS and COS groups compared to the corresponding levels in the control group. Collectively, the results indicate the oral administration of NACOS and COS could enhance innate immunity. Results of experiments in Myd-88 knockout mice revealed that the apparent effects were related to both Myd-88-dependent and Myd-88-independent pathways. The data indicated that oral administration of NACOS and COS produced anti-tumor effects through the induction of Apoptosis and stimulation of the immune system, which suggests that NACOS and COS are candidate anti-tumor functional foods.

Keywords

Chitin oligosaccharide; Chitosan oligosaccharide; Colon-26; Functional food; Mice; Tumor growth.

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