2. Academic Validation
  3. A new phenylpropanoid and an alkylglycoside from Piper retrofractum leaves with their antioxidant and α-glucosidase inhibitory activity

A new phenylpropanoid and an alkylglycoside from Piper retrofractum leaves with their antioxidant and α-glucosidase inhibitory activity

  • Bioorg Med Chem Lett. 2014 Sep 1;24(17):4120-4. doi: 10.1016/j.bmcl.2014.07.057.
Bui Thi Thuy Luyen 1,  Bui Huu Tai 2,  Nguyen Phuong Thao 2,  Seo Young Yang 1,  Nguyen Manh Cuong 3,  Young In Kwon 4,  Hae Dong Jang 4,  Young Ho Kim 5
Affiliations

Affiliations

  • 1 College of Pharmacy, Chungnam National University, Daejeon 305-764, Republic of Korea.
  • 2 College of Pharmacy, Chungnam National University, Daejeon 305-764, Republic of Korea; Institute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam.
  • 3 Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam.
  • 4 Department of Food and Nutrition, Hannam University, Daejeon 305-811, Republic of Korea.
  • 5 College of Pharmacy, Chungnam National University, Daejeon 305-764, Republic of Korea. Electronic address: yhk@cnu.ac.kr.
PMID: 25127165 DOI: 10.1016/j.bmcl.2014.07.057
Abstract

Two new compounds, piperoside (1) and isoheptanol 2(S)-O-β-D-xylopyranosyl (1→6)-O-β-D-glucopyranoside (11), along with 10 known compounds 3,4-dihydroxyallylbenzene (2), 1,2-di-O-β-D-glucopyranosyl-4-allylbenzene (3), tachioside (4), benzyl-O-β-D-glucopyranoside (5), icariside F2 (6), dihydrovomifoliol-3'-O-β-D-glucopyranoside (7), isopropyl O-β-D-glucopyranoside (8), isopropyl primeveroside (9), n-butyl O-β-D-glucopyranoside (10), isoheptanol 2(S)-O-β-D-apiofuranosyl-(1→6)-O-β-D-glucopyranoside (12), were isolated from the leaves of Piper retrofractum. Their structures were determined from 1D-NMR, 2D-NMR, and HR-ESI-MS spectral, a modified Mosher's method, and comparisons with previous reports. All of the isolated compounds showed modest α-glucosidase inhibitory (4.60±1.74% to 11.97±3.30%) and antioxidant activities under the tested conditions.

Keywords

Antioxidant; Isoheptanol 2(S)-O-β-d-xylopyranosyl (1→6)-O-β-d-glucopyranoside; Piper retrofractum; Piperoside; α-Glucosidase inhibitor.

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