2. Academic Validation
  3. The first synthesis of the antiangiogenic homoisoflavanone, cremastranone

The first synthesis of the antiangiogenic homoisoflavanone, cremastranone

  • Org Biomol Chem. 2014 Oct 21;12(39):7673-7. doi: 10.1039/c4ob01604a.
Bit Lee 1,  Halesha D Basavarajappa,  Rania S Sulaiman,  Xiang Fei,  Seung-Yong Seo,  Timothy W Corson
Affiliations

Affiliation

  • 1 College of Pharmacy and Gachon Institute of Pharmaceutical Sciences, Gachon University, Incheon, South Korea. syseo@gachon.ac.kr.
PMID: 25167470 DOI: 10.1039/c4ob01604a
Abstract

An antiangiogenic homoisoflavanone, cremastranone, was synthesized for the first time. This scalable synthesis, which includes selective demethylation, could be used to develop lead molecules to treat angiogenesis-induced eye diseases. Synthetic cremastranone inhibited the proliferation, migration and tube formation ability of human retinal microvascular endothelial cells, important steps in pathological angiogenesis.

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