2. Academic Validation
  3. Notolutesins A-J, dolabrane-type diterpenoids from the Chinese liverwort Notoscyphus lutescens

Notolutesins A-J, dolabrane-type diterpenoids from the Chinese liverwort Notoscyphus lutescens

  • J Nat Prod. 2014 Sep 26;77(9):2081-7. doi: 10.1021/np5004559.
Song Wang 1,  Rui-Juan Li,  Rong-Xiu Zhu,  Xiao-Yan Hu,  Yan-Xia Guo,  Jin-Chuan Zhou,  Zhao-Min Lin,  Jiao-Zhen Zhang,  Jing-Yi Wu,  Ya-Qi Kang,  Susan L Morris-Natschke,  Kuo-Hsiung Lee,  Hui-Qing Yuan,  Hong-Xiang Lou
Affiliations

Affiliation

  • 1 Department of Natural Products Chemistry, Key Laboratory of Chemical Biology of the Ministry of Education, School of Pharmaceutical Science, Shandong University , Jinan 250012, People's Republic of China.
PMID: 25226363 DOI: 10.1021/np5004559
Abstract

Ten new dolabrane-type Diterpenoids, notolutesins A-J (1-10), were isolated from the Chinese liverwort Notoscyphus lutescens, along with four known compounds. The structures of the new compounds were established on the basis of extensive spectroscopic data, and that of 1 was confirmed by single-crystal X-ray crystallography. The absolute configuration of 1 was determined by comparing its experimental and calculated electronic circular dichroism spectra. All of the isolates were evaluated for their cytotoxicity against a small panel of human Cancer cell lines, and compound 1 exhibited an IC50 value of 6.2 μM against the PC3 human prostate Cancer cell line.

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