2. Academic Validation
  3. Bisdemethoxycurcumin attenuates gastric adenocarcinoma growth by inducing mitochondrial dysfunction

Bisdemethoxycurcumin attenuates gastric adenocarcinoma growth by inducing mitochondrial dysfunction

  • Oncol Lett. 2015 Jan;9(1):270-274. doi: 10.3892/ol.2014.2685.
Changjiang Luo 1,  Zhixing DU 2,  Xing Wei 3,  Gang Chen 2,  Zhongxue Fu 4
Affiliations

Affiliations

  • 1 Department of Gastrointestinal Surgery, The First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, P.R. China ; Department of General Surgery, Lanzhou University Second Hospital, Lanzhou, Gansu 730030, P.R. China.
  • 2 Department of General Surgery, Lanzhou University Second Hospital, Lanzhou, Gansu 730030, P.R. China.
  • 3 Department of Surgical ICU, Lanzhou University Second Hospital, Lanzhou, Gansu 730030, P.R. China.
  • 4 Department of Gastrointestinal Surgery, The First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, P.R. China.
PMID: 25435973 DOI: 10.3892/ol.2014.2685
Abstract

Bisdemethoxycurcumin (BDMC) is a demethoxy derivative of curcumin. In this study, a human gastric adenocarcinoma xenograft model was generated in vivo using nude mice and BDMC was observed to suppress the growth and activity of tumors, in addition to improving the physical and mental capacity of the mice. An increased number of apoptotic cells, decreased ratio of B-cell lymphoma 2 (Bcl-2)/Bcl-2-associated X protein and increased Caspase-3 expression was also observed following treatment with BDMC, indicating that BDMC may promote Apoptosis in tumors via mitochondrial modulation. The growth of SGC 7901 gastric Cancer cells was inhibited and arrested at G1 phase. Specific indicators of mitochondrial dysfunction, a reduction in adenosine triphosphate generation, the inner mitochondrial membrane potential, augmentation of Reactive Oxygen Species production and cytochrome c were also detected in the mitochondria following treatment with BDMC. These results indicate that BDMC attenuates gastric adenocarcinoma growth by inducing mitochondrial dysfunction.

Keywords

apoptosis; bisdemethoxycurcumin; gastric adenocarcinoma; mitochondria; tumor growth inhibition.

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