2. Academic Validation
  3. Amino acid modified xanthone derivatives: novel, highly promising membrane-active antimicrobials for multidrug-resistant Gram-positive bacterial infections

Amino acid modified xanthone derivatives: novel, highly promising membrane-active antimicrobials for multidrug-resistant Gram-positive bacterial infections

  • J Med Chem. 2015 Jan 22;58(2):739-52. doi: 10.1021/jm501285x.
Jun-Jie Koh 1,  Shuimu Lin,  Thet Tun Aung,  Fanghui Lim,  Hanxun Zou,  Yang Bai,  Jianguo Li,  Huifen Lin,  Li Mei Pang,  Wee Luan Koh,  Shuhaida Mohamed Salleh,  Rajamani Lakshminarayanan,  Lei Zhou,  Shengxiang Qiu,  Konstantin Pervushin,  Chandra Verma,  Donald T H Tan,  Derong Cao,  Shouping Liu,  Roger W Beuerman
Affiliations

Affiliation

  • 1 Singapore Eye Research Institute , 11 Third Hospital Avenue, 168751, Singapore.
PMID: 25474410 DOI: 10.1021/jm501285x
Abstract

Antibiotic resistance is a critical global health care crisis requiring urgent action to develop more effective Antibiotics. Utilizing the hydrophobic scaffold of xanthone, we identified three components that mimicked the action of an antimicrobial cationic peptide to produce membrane-targeting antimicrobials. Compounds 5c and 6, which contain a hydrophobic xanthone core, lipophilic chains, and cationic Amino acids, displayed very promising antimicrobial activity against multidrug-resistant Gram-positive bacteria, including MRSA and VRE, rapid time-kill, avoidance of Antibiotic resistance, and low toxicity. The Bacterial membrane selectivity of these molecules was comparable to that of several membrane-targeting Antibiotics in clinical trials. 5c and 6 were effective in a mouse model of corneal Infection by S. aureus and MRSA. Evidence is presented indicating that 5c and 6 target the negatively charged Bacterial membrane via a combination of electrostatic and hydrophobic interactions. These results suggest that 5c and 6 have significant promise for combating life-threatening infections.

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