2. Academic Validation
  3. Two new phenolic glucosides from Lagerstroemia speciosa

Two new phenolic glucosides from Lagerstroemia speciosa

  • Molecules. 2015 Mar 10;20(3):4483-91. doi: 10.3390/molecules20034483.
Janggyoo Choi 1,  Jae Youl Cho 2,  Soo Jung Choi 3,  Heejin Jeon 4,  Young Dong Kim 5,  Khin Myo Htwe 6,  Young Won Chin 7,  Woo Shin Lee 8,  Jinwoong Kim 1,  Kee Dong Yoon 9
Affiliations

Affiliations

  • 1 College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Seoul 151-742, Korea. dashutiao@naver.com.
  • 2 Department of Genetic Engineering, Sungkyunkwan University, Suwon 440-746, Korea. jaecho@skku.edu.
  • 3 College of Pharmacy, The Catholic University of Korea, Bucheon 420-743, Korea. wjd6694@naver.com.
  • 4 College of Pharmacy, The Catholic University of Korea, Bucheon 420-743, Korea. tkghs35@naver.com.
  • 5 Department of Life Science, Hallym University, Chuncheon 200-702, Korea. ydkim@hallym.ac.kr.
  • 6 Popa mountain park, Forest Department, Kyaukpadaung Township, Mandalay Division, Myanmar. khinmyohtwe007@gmail.com.
  • 7 College of Pharmacy and RFIND-BKplus Team, Dongguk University-Seoul, 32 Dongguk-lo, Ilsan dong-gu, Goyang 410-820, Korea. f2744@dongguk.edu.
  • 8 Department of Forest Sciences, Seoul National University, Seoul 151-921, Korea. krane@snu.ac.kr.
  • 9 College of Pharmacy, The Catholic University of Korea, Bucheon 420-743, Korea. kdyoon@catholic.ac.kr.
PMID: 25764490 DOI: 10.3390/molecules20034483
Abstract

Two new phenolic glucosides, 1-O-benzyl-6-O-E-caffeoyl-β-d-glucopyranoside and 1-O-(7S,8R)-guaiacylglycerol-(6-O-E-caffeoyl)-β-d-glucopyranoside, were isolated from the aerial parts of Lagerstroemia speciosa, along with ten known compounds. The structures of the isolated compounds were determined based on 1D- and 2D-NMR, Q-TOF MS and optical rotation spectroscopic data. All of the compounds showed moderate inhibitory activities against nitric oxide production in lipopolysaccharide-treated RAW264.7 cells, with IC50 values of 69.5-83.3 μM.

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