1. Academic Validation
  2. Two new phenolic glucosides from Lagerstroemia speciosa

Two new phenolic glucosides from Lagerstroemia speciosa

  • Molecules. 2015 Mar 10;20(3):4483-91. doi: 10.3390/molecules20034483.
Janggyoo Choi 1 Jae Youl Cho 2 Soo Jung Choi 3 Heejin Jeon 4 Young Dong Kim 5 Khin Myo Htwe 6 Young Won Chin 7 Woo Shin Lee 8 Jinwoong Kim 1 Kee Dong Yoon 9
Affiliations

Affiliations

  • 1 College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Seoul 151-742, Korea. dashutiao@naver.com.
  • 2 Department of Genetic Engineering, Sungkyunkwan University, Suwon 440-746, Korea. jaecho@skku.edu.
  • 3 College of Pharmacy, The Catholic University of Korea, Bucheon 420-743, Korea. wjd6694@naver.com.
  • 4 College of Pharmacy, The Catholic University of Korea, Bucheon 420-743, Korea. tkghs35@naver.com.
  • 5 Department of Life Science, Hallym University, Chuncheon 200-702, Korea. ydkim@hallym.ac.kr.
  • 6 Popa mountain park, Forest Department, Kyaukpadaung Township, Mandalay Division, Myanmar. khinmyohtwe007@gmail.com.
  • 7 College of Pharmacy and RFIND-BKplus Team, Dongguk University-Seoul, 32 Dongguk-lo, Ilsan dong-gu, Goyang 410-820, Korea. f2744@dongguk.edu.
  • 8 Department of Forest Sciences, Seoul National University, Seoul 151-921, Korea. krane@snu.ac.kr.
  • 9 College of Pharmacy, The Catholic University of Korea, Bucheon 420-743, Korea. kdyoon@catholic.ac.kr.
Abstract

Two new phenolic glucosides, 1-O-benzyl-6-O-E-caffeoyl-β-d-glucopyranoside and 1-O-(7S,8R)-guaiacylglycerol-(6-O-E-caffeoyl)-β-d-glucopyranoside, were isolated from the aerial parts of Lagerstroemia speciosa, along with ten known compounds. The structures of the isolated compounds were determined based on 1D- and 2D-NMR, Q-TOF MS and optical rotation spectroscopic data. All of the compounds showed moderate inhibitory activities against nitric oxide production in lipopolysaccharide-treated RAW264.7 cells, with IC50 values of 69.5-83.3 μM.

Figures
Products