2. Academic Validation
  3. A concise formal total synthesis of lactimidomycin

A concise formal total synthesis of lactimidomycin

  • Chem Commun (Camb). 2015 May 21;51(41):8634-6. doi: 10.1039/c5cc02571k.
Wei Li 1,  Gunda I Georg
Affiliations

Affiliation

  • 1 Department of Chemistry, Department of Medicinal Chemistry and the Institute for Therapeutics Discovery and Development, University of Minnesota, 717 Delaware Street SE, Minneapolis, MN 55414, USA. Georg@umn.edu.
PMID: 25900419 DOI: 10.1039/c5cc02571k
Abstract

A formal total synthesis of the cytotoxic natural product lactimidomycin has been achieved in nine steps from (E)-2-methyl-2-pentenoic acid. The 12-membered lactone was efficiently formed via a copper-catalyzed ene-yne coupling/alkyne reduction tandem reaction.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z