2. Academic Validation
  3. Koumine, Humantenine, and Yohimbane Alkaloids from Gelsemium elegans

Koumine, Humantenine, and Yohimbane Alkaloids from Gelsemium elegans

  • J Nat Prod. 2015 Jul 24;78(7):1511-7. doi: 10.1021/np5009619.
You-Kai Xu 1,  Lin Yang 1,  Shang-Gao Liao 2,  Pei Cao 3,  Bin Wu 3,  Hua-Bin Hu 1,  Juan Guo 1,  Ping Zhang 1
Affiliations

Affiliations

  • 1 †Key Laboratory of Tropical Plant Resources and Sustainable Use, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Menglun, Mengla, Yunnan 666303, People's Republic of China.
  • 2 ‡Engineering Research Center for the Development and Application of Ethnic Medicines and TCM, School of Pharmacy, Guiyang Medical College, 9 Beijing Road, Guiyang, Guizhuo 550004, People's Republic of China.
  • 3 §State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming, Yunnan 650201, People's Republic of China.
PMID: 26103517 DOI: 10.1021/np5009619
Abstract

Nine new Alkaloids of the koumine (1-4), humantenine (5-7), and yohimbane (8, 9) types as well as 12 known analogues were isolated from the leaves and vine stems of Gelsemium elegans. Compound 1 is the first N-4-demethyl alkaloid of the koumine type, compound 7 is the first nor-humantenine alkaloid, and compounds 8 and 9 are the first N-1-oxide and the first seco-E-ring Alkaloids, respectively, of the yohimbane type. Compounds 1 and 7 exhibited moderate cytotoxicity against five human tumor cell lines with IC50 values in the range 4.6-9.3 μM.

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