1. Academic Validation
  2. Identification of glabridin as a bioactive compound in licorice (Glycyrrhiza glabra L.) extract that activates human peroxisome proliferator-activated receptor gamma (PPARγ)

Identification of glabridin as a bioactive compound in licorice (Glycyrrhiza glabra L.) extract that activates human peroxisome proliferator-activated receptor gamma (PPARγ)

  • Fitoterapia. 2015 Oct;106:55-61. doi: 10.1016/j.fitote.2015.08.004.
John F Rebhun 1 Kelly M Glynn 2 Stephen R Missler 2
Affiliations

Affiliations

  • 1 Analytical Sciences, Amway Corporation, 7575 East Fulton Avenue, Ada, MI 49355, United States. Electronic address: john.rebhun@Amway.com.
  • 2 Analytical Sciences, Amway Corporation, 7575 East Fulton Avenue, Ada, MI 49355, United States.
Abstract

Licorice, the root and stolons of the Glycyrrhiza plant (Fabaceae), has been used for centuries as a food additive (sweetener), in cosmetics, and in traditional medicine. In this research, we provide evidence that licorice extract activates Peroxisome Proliferator-activated Receptor gamma (PPARγ) and, as identified through HPLC fractionation and mass spectroscopy, one of the activating phytochemicals is glabridin. Glabridin was shown to bind to and activate PPARγ. It was also shown to activate PPARγ-regulated gene expression in human hepatoma cells similar to known PPARγ ligands and that the expression was blocked by a PPARγ specific antagonist.

Keywords

Glabrene; Glabridin; Glycyrrhetinic acid; Glycyrrhiza glabra L; Glycyrrhizin; Licorice; Licorice extract; Peroxisome proliferator-activated receptor gamma (PPARγ); T0070907; Troglitazone.

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