2. Academic Validation
  3. Isolation and Structure of Kurahyne B and Total Synthesis of the Kurahynes

Isolation and Structure of Kurahyne B and Total Synthesis of the Kurahynes

  • J Nat Prod. 2015 Nov 25;78(11):2719-25. doi: 10.1021/acs.jnatprod.5b00662.
Shinichiro Okamoto 1,  Arihiro Iwasaki 1,  Osamu Ohno 1,  Kiyotake Suenaga 1
Affiliations

Affiliation

  • 1 Department of Chemistry, Faculty of Science and Technology, Keio University , 3-14-1 Hiyoshi, Kohoku, Yokohama, Kanagawa 223-8522, Japan.
PMID: 26539973 DOI: 10.1021/acs.jnatprod.5b00662
Abstract

Kurahyne B (2), a new analogue of kurahyne (1), was isolated from the marine cyanobacterium Okeania sp. Its gross structure was elucidated based on spectroscopic analyses, and the absolute configuration was established by total synthesis. Kurahyne B (2) inhibited the growth of both HeLa and HL60 cells, with IC50 values of 8.1 and 9.0 μM, respectively. The growth-inhibitory activity of kurahyne B was the same as kurahyne (1). In parallel, the first total synthesis of kurahyne (1) was also achieved.

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