2. Academic Validation
  3. EPPS rescues hippocampus-dependent cognitive deficits in APP/PS1 mice by disaggregation of amyloid-β oligomers and plaques

EPPS rescues hippocampus-dependent cognitive deficits in APP/PS1 mice by disaggregation of amyloid-β oligomers and plaques

  • Nat Commun. 2015 Dec 8;6:8997. doi: 10.1038/ncomms9997.
Hye Yun Kim 1 2 3,  Hyunjin Vincent Kim 1 2,  Seonmi Jo 4,  C Justin Lee 4,  Seon Young Choi 1,  Dong Jin Kim 1,  YoungSoo Kim 1 2
Affiliations

Affiliations

  • 1 Center for Neuro-Medicine, Brain Science Institute, Korea Institute of Science and Technology (KIST), Hwarangno 14-gil 5, Seongbuk-gu, Seoul 136-791, Republic of Korea.
  • 2 Biological Chemistry Program, Korea University of Science and Technology (UST), 217 Gajungro Yuseong-gu, Daegeon 305-806, Republic of Korea.
  • 3 Research Institute, GoshenBiotech Inc., 78, Sure-ro 640beon-gil, Wabu-eup, Namyangju-si, Gyeonggi-do 472-905, Republic of Korea.
  • 4 Center for Neuroscience, Brain Science Institute, Korea Institute of Science and Technology (KIST), Hwarangno 14-gil 5, Seongbuk-gu, Seoul 136-791, Republic of Korea.
PMID: 26646366 DOI: 10.1038/ncomms9997
Abstract

Alzheimer's disease (AD) is characterized by the transition of Amyloid-β (Aβ) monomers into toxic oligomers and plaques. Given that Aβ abnormality typically precedes the development of clinical symptoms, an agent capable of disaggregating existing Aβ aggregates may be advantageous. Here we report that a small molecule, 4-(2-hydroxyethyl)-1-piperazinepropanesulphonic acid (EPPS), binds to Aβ aggregates and converts them into monomers. The oral administration of EPPS substantially reduces hippocampus-dependent behavioural deficits, brain Aβ oligomer and plaque deposits, glial γ-aminobutyric acid (GABA) release and brain inflammation in an Aβ-overexpressing, APP/PS1 transgenic mouse model when initiated after the development of severe AD-like phenotypes. The ability of EPPS to rescue Aβ aggregation and behavioural deficits provides strong support for the view that the accumulation of Aβ is an important mechanism underlying AD.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z