2. Academic Validation
  3. Fosfomycin

Fosfomycin

  • Clin Microbiol Rev. 2016 Apr;29(2):321-47. doi: 10.1128/CMR.00068-15.
Matthew E Falagas 1,  Evridiki K Vouloumanou 2,  George Samonis 3,  Konstantinos Z Vardakas 4
Affiliations

Affiliations

  • 1 Alfa Institute of Biomedical Sciences, Athens, Greece Department of Internal Medicine-Infectious Diseases, Iaso General Hospital, Iaso Group, Athens, Greece Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts, USA m.falagas@aibs.gr.
  • 2 Alfa Institute of Biomedical Sciences, Athens, Greece.
  • 3 Department of Internal Medicine, University of Crete School of Medicine, Heraklion, Greece.
  • 4 Alfa Institute of Biomedical Sciences, Athens, Greece Department of Internal Medicine-Infectious Diseases, Iaso General Hospital, Iaso Group, Athens, Greece.
PMID: 26960938 DOI: 10.1128/CMR.00068-15
Abstract

The treatment of Bacterial infections suffers from two major problems: spread of multidrug-resistant (MDR) or extensively drug-resistant (XDR) pathogens and lack of development of new Antibiotics active against such MDR and XDR bacteria. As a result, physicians have turned to older Antibiotics, such as polymyxins, tetracyclines, and aminoglycosides. Lately, due to development of resistance to these agents, fosfomycin has gained attention, as it has remained active against both Gram-positive and Gram-negative MDR and XDR bacteria. New data of higher quality have become available, and several issues were clarified further. In this review, we summarize the available fosfomycin data regarding pharmacokinetic and pharmacodynamic properties, the in vitro activity against susceptible and antibiotic-resistant bacteria, mechanisms of resistance and development of resistance during treatment, synergy and antagonism with Other Antibiotics, clinical effectiveness, and adverse events. Issues that need to be studied further are also discussed.

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