2. Academic Validation
  3. Euphorins A-H: bioactive diterpenoids from Euphorbia fischeriana

Euphorins A-H: bioactive diterpenoids from Euphorbia fischeriana

  • J Nat Med. 2016 Jul;70(3):412-22. doi: 10.1007/s11418-016-0987-z.
Xinzhu Kuang 1,  Wei Li 2,  Yuichiro Kanno 3,  Naoya Yamashita 3,  Shoko Kikkawa 1,  Isao Azumaya 1,  Kiyomitsu Nemoto 3,  Yoshihisa Asada 4,  Kazuo Koike 1
Affiliations

Affiliations

  • 1 Faculty of Pharmaceutical Sciences, Toho University, Miyama 2-2-1, Funabashi, Chiba, 274-8510, Japan.
  • 2 Faculty of Pharmaceutical Sciences, Toho University, Miyama 2-2-1, Funabashi, Chiba, 274-8510, Japan. liwei@phar.toho-u.ac.jp.
  • 3 Department of Molecular Toxicology, Faculty of Pharmaceutical Sciences, Toho University, Miyama 2-2-1, Funabashi, Chiba, 274-8510, Japan.
  • 4 Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba, 278-8510, Japan.
PMID: 27000121 DOI: 10.1007/s11418-016-0987-z
Abstract

Phytochemical investigation of the roots of Euphorbia fischeriana resulted in the isolation of 23 Diterpenoids (1-23), which were classified into five subtypes, namely, ent-rosane (1-9), ent-abietane (10-16), ent-kaurane (17), ingenane (18-22), and lathyrane (23). The chemical structures of eight new compounds, namely, euphorin A (4), B (5), C (7), D (9), E (13), F (14), G (15), and H (16), were elucidated on the basis of extensive 1D and 2D NMR spectroscopic analyses, as well as single crystal X-ray structure analysis. A number of compounds (2, 6, 7, 10, 11, 13, 16, 19, 20, 22, and 23) showed inhibitory activity on the formation of mammospheres in human breast Cancer MCF-7 cells at a final concentration of 10 μM, suggesting the potential of these bioactive Diterpenoids for further investigation of the action targeting Cancer Stem Cells.

Keywords

Cancer stem cells; Diterpenoid; Euphorbia fischeriana; Euphorbiaceae; Mammosphere formation.

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