2. Academic Validation
  3. Prospects for Creation of Cardioprotective and Antiarrhythmic Drugs Based on Opioid Receptor Agonists

Prospects for Creation of Cardioprotective and Antiarrhythmic Drugs Based on Opioid Receptor Agonists

  • Med Res Rev. 2016 Sep;36(5):871-923. doi: 10.1002/med.21395.
Leonid N Maslov 1,  Igor Khaliulin 2,  Peter R Oeltgen 3,  Natalia V Naryzhnaya 1,  Jian-Ming Pei 4,  Stephen A Brown 3,  Yury B Lishmanov 1 5,  James M Downey 6
Affiliations

Affiliations

  • 1 Research Institute for Cardiology, Tomsk, Russia.
  • 2 School of Clinical Sciences, University of Bristol, Bristol, UK.
  • 3 VA Medical Center, University of Kentucky, Lexington, KY.
  • 4 Department of Physiology, Fourth Military Medical University, Xi'an, P. R. China.
  • 5 National Research Tomsk Polytechnic University, 634050, Tomsk, Russia.
  • 6 University of South Alabama, Mobile, AL.
PMID: 27197922 DOI: 10.1002/med.21395
Abstract

It has now been demonstrated that the μ, δ1 , δ2 , and κ1 Opioid Receptor (OR) agonists represent the most promising group of opioids for the creation of drugs enhancing cardiac tolerance to the detrimental effects of ischemia/reperfusion (I/R). Opioids are able to prevent necrosis and Apoptosis of cardiomyocytes during I/R and improve cardiac contractility in the reperfusion period. The OR agonists exert an infarct-reducing effect with prophylactic administration and prevent reperfusion-induced cardiomyocyte death when ischemic injury of heart has already occurred; that is, opioids can mimic preconditioning and postconditioning phenomena. Furthermore, opioids are also effective in preventing ischemia-induced arrhythmias.

Keywords

cardioprotection; heart; ischemia/reperfusion injury; opioids; signal transduction.

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