1. Academic Validation
  2. Preventive effect of MK-733 (simvastatin), an inhibitor of HMG-CoA reductase, on hypercholesterolemia and atherosclerosis induced by cholesterol feeding in rabbits

Preventive effect of MK-733 (simvastatin), an inhibitor of HMG-CoA reductase, on hypercholesterolemia and atherosclerosis induced by cholesterol feeding in rabbits

  • Jpn J Pharmacol. 1989 Jan;49(1):125-33. doi: 10.1254/jjp.49.125.
M Kobayashi 1 F Ishida T Takahashi K Taguchi K Watanabe I Ohmura T Kamei
Affiliations

Affiliation

  • 1 Central Research Laboratories, Banyu Pharmaceutical Co., Ltd., Tokyo, Japan.
Abstract

MK-733 was found to prevent an increase of serum Cholesterol levels in cholesterol-fed rabbits, and lovastatin also markedly inhibited their increase. MK-733 and lovastatin inhibited the increase of very low density lipoprotein (VLDL) and low density lipoprotein (LDL) Cholesterol, and it slightly affected the high density lipoprotein (HDL) Cholesterol levels. MK-733 and lovastatin suppressed the increase of serum phospholipid levels and slightly affected the triglyceride levels. MK-733 suppressed the development of atherosclerosis in coronary arteries and aorta, and lovastatin also diminished their development.

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