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  3. Synthesis and cytotoxic activities of semisynthetic zearalenone analogues

Synthesis and cytotoxic activities of semisynthetic zearalenone analogues

  • Bioorg Med Chem Lett. 2016 Aug 1;26(15):3612-6. doi: 10.1016/j.bmcl.2016.06.007.
Kwanruthai Tadpetch 1,  Benyapa Kaewmee 2,  Kittisak Chantakaew 2,  Kawalee Kantee 2,  Vatcharin Rukachaisirikul 2,  Souwalak Phongpaichit 3
Affiliations

Affiliations

  • 1 Department of Chemistry and Center of Excellence for Innnovation in Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand. Electronic address: kwanruthai.t@psu.ac.th.
  • 2 Department of Chemistry and Center of Excellence for Innnovation in Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand.
  • 3 Department of Microbiology and Natural Products Research Center of Excellence, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand.
PMID: 27311894 DOI: 10.1016/j.bmcl.2016.06.007
Abstract

Zearalenone is a β-resorcylic acid Macrolide with various biological activities. Herein we report the synthesis and cytotoxic activities of 34 zearalenone analogues against human oral epidermoid carcinoma (KB) and human breast adenocarcinoma (MCF-7) cells as well as noncancerous Vero cells. Some zearalenone analogues showed moderately enhanced cytotoxic activities against the two Cancer cell lines. We have discovered the potential lead compounds with diminished or no cytotoxicity to Vero cells. Preliminary structure-activity relationship studies revealed that the double bond at the 1' and 2' positions of zearalenone core was crucial for cytotoxic activities on both cell lines. In addition, for zearalenol analogues, the unprotected hydroxyl group at C-2 and an alkoxy substituent at C-4 played key roles on cytotoxic effects of both cell lines.

Keywords

Cytotoxicity; Structure modification; Structure–activity relationship; Zearalenone.

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