2. Academic Validation
  3. Bioactive Coumarins from the Stems of Clausena emarginata

Bioactive Coumarins from the Stems of Clausena emarginata

  • Chem Biodivers. 2016 Sep;13(9):1178-1185. doi: 10.1002/cbdv.201500519.
Guo-Qing Ouyang 1,  Chuang-Jun Li 1,  Jing-Zhi Yang 1,  Li Li 1,  Xiu-Yun Song 1,  Yi-Na Jiang 1,  Nai-Hong Chen 1,  Jie Ma 2,  Dong-Ming Zhang 3
Affiliations

Affiliations

  • 1 State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, P. R. China.
  • 2 State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, P. R. China. majie@imm.ac.cn.
  • 3 State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, P. R. China. zhangdm@imm.ac.cn.
PMID: 27450780 DOI: 10.1002/cbdv.201500519
Abstract

Five new Coumarins, clauemarmarins I - M (1 - 4), together with 10 known analogs (5 - 14), were isolated from the stems of Clausena emarginata. Compounds 8 - 13 were obtained from this plant for the first time. Their structures were established and elucidated by comprehensive analysis of spectroscopic data. The absolute configurations of 1 - 4 were further determined by their electronic circular dichroism spectroscopy. Compounds 5, 7, 12, and 14 exhibited inhibitory effects on LPS-induced NO production. Compounds 5 - 7 showed selective neuroprotective effects in Aβ25 - 35 model at 10 μm.

Keywords

Clauemarmarins; Clausena emarginata; Inhibitory effects; Neuroprotective effects; Stems.

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