2. Academic Validation
  3. Repeated-doses and reproductive toxicity studies of the monoterpene 1,8-cineole (eucalyptol) in Wistar rats

Repeated-doses and reproductive toxicity studies of the monoterpene 1,8-cineole (eucalyptol) in Wistar rats

  • Food Chem Toxicol. 2016 Nov;97:297-306. doi: 10.1016/j.fct.2016.09.020.
Germana Freire Rocha Caldas 1,  Mayara Marília Ferreira Limeira 2,  Alice Valença Araújo 3,  Giwellington Silva Albuquerque 4,  Jacinto da Costa Silva-Neto 4,  Teresinha Gonçalves da Silva 5,  João Henrique Costa-Silva 6,  Irwin Rose Alencar de Menezes 7,  José Galberto Martins da Costa 7,  Almir Gonçalves Wanderley 8
Affiliations

Affiliations

  • 1 Department of Pharmaceutical Sciences, Federal University of Pernambuco, 50740-521, Recife, PE, Brazil.
  • 2 Department of Physiology and Pharmacology, Federal University of Pernambuco, 50670-901, Recife, PE, Brazil.
  • 3 Department of Public Health, Federal University of Pernambuco, Vitória de Santo Antão, 55608-680, Recife, PE, Brazil.
  • 4 Department of Histology and Embryology, Federal University of Pernambuco, 50670-901, Recife, PE, Brazil.
  • 5 Department of Antibiotics, Federal University of Pernambuco, 50670-901, Recife, PE, Brazil.
  • 6 Department of Physical Education and Sport Sciences, Federal University of Pernambuco, Vitória de Santo Antão, 55608-680, Recife, PE, Brazil.
  • 7 Department of Biological Chemistry, Regional University of Cariri, 63105-000, Crato, CE, Brazil.
  • 8 Department of Pharmaceutical Sciences, Federal University of Pernambuco, 50740-521, Recife, PE, Brazil; Department of Physiology and Pharmacology, Federal University of Pernambuco, 50670-901, Recife, PE, Brazil. Electronic address: almir.wanderley@ufpe.br.
PMID: 27644596 DOI: 10.1016/j.fct.2016.09.020
Abstract

1,8-cineole (eucalyptol) is widely used as an excipient in the pharmaceutical industry and as a food flavoring agent, thus providing significant potential for human exposure to the compound. We investigated the preclinical toxicity and reproductive toxicity of 1,8-cineole (CIN). In the repeated-doses toxicity study for 50 days, CIN (100, 500 or 1000 mg/kg) did not produce any signs of toxicity or deaths, but affected body weight gain during the first week of treatment. The hematological and biochemical profiles did not show significant differences except for increase in the MCV, platelet and urea levels or reduction in MCHC, MPV and Alkaline Phosphatase. Histopathological analysis showed weak changes in the lungs, liver, kidneys and uterus. In the reproductive toxicity, CIN (250, 500 or 1000 mg/kg) produced a reduction in body weight in pregnant rats treated during the pre-implantation or organogenesis periods. The highest doses induced a reduction in the mass of fetuses (pre-implantation) and dead fetuses (both periods) of pregnant rats. The results indicate that the treatment by repeated-doses showed occasional alterations in rats of both sexes. However, provide evidence that possibly 1,8-cineole presents maternal and fetal toxicity. This requires more detailed investigation to better characterize the toxic effects of this compound.

Keywords

1,8-Cineole; Monoterpene; Repeated dose toxicity; Reproductive toxicity.

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