2. Academic Validation
  3. Eriocitrin from lemon suppresses the proliferation of human hepatocellular carcinoma cells through inducing apoptosis and arresting cell cycle

Eriocitrin from lemon suppresses the proliferation of human hepatocellular carcinoma cells through inducing apoptosis and arresting cell cycle

  • Cancer Chemother Pharmacol. 2016 Dec;78(6):1143-1150. doi: 10.1007/s00280-016-3171-y.
Ziyou Wang 1 2,  Hua Zhang 1 2,  Jiahui Zhou 1 2,  Xiangning Zhang 1 2,  Liyong Chen 1 2,  Kangxing Chen 1 2,  Zunnan Huang 3 4
Affiliations

Affiliations

  • 1 Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Dongguan, 523808, China.
  • 2 China-America Cancer Research Institute, Dongguan Key Laboratory of Epigenetics, Dongguan Scientific Research Center, Guangdong Medical University, Dongguan, 523808, China.
  • 3 Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Dongguan, 523808, China. zn_huang@yahoo.com.
  • 4 China-America Cancer Research Institute, Dongguan Key Laboratory of Epigenetics, Dongguan Scientific Research Center, Guangdong Medical University, Dongguan, 523808, China. zn_huang@yahoo.com.
PMID: 27766389 DOI: 10.1007/s00280-016-3171-y
Abstract

Hepatocellular carcinoma is a lethal Cancer with high recurrence ratio and lacks effective therapeutics. In the past few years, it has been reported that increased intake of vegetables and fruits could reduce the Cancer incidence, which suggests dietary agents might possess Anticancer effects. Eriocitrin is a flavonoid isolated from lemon, which is known as a strong antioxidant agent. We here for the first time demonstrated that eriocitrin could inhibit the proliferation of hepatocellular carcinoma cell lines by arresting cell cycle in S phase through up-regulation of p53, cyclin A, cyclin D3 and CDK6. Furthermore, we found that eriocitrin could trigger Apoptosis by activating mitochondria-involved intrinsic signaling pathway. Thus, eriocitrin might be regarded as a potential chemopreventive natural product to inhibit the early malignant transformation of hepatocellular carcinoma.

Keywords

Apoptosis; Cell cycle arrest; Eriocitrin; Hepatocellular carcinoma.

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