2. Academic Validation
  3. Cytotoxic Fusicoccane-Type Diterpenoids from Streptomyces violascens Isolated from Ailuropoda melanoleuca Feces

Cytotoxic Fusicoccane-Type Diterpenoids from Streptomyces violascens Isolated from Ailuropoda melanoleuca Feces

  • J Nat Prod. 2017 Apr 28;80(4):837-844. doi: 10.1021/acs.jnatprod.6b00676.
Dan Zheng 1 2,  Li Han 1,  Xiaodan Qu 1,  Xiu Chen 3,  Jialiang Zhong 4,  Xiaoxu Bi 1,  Jiang Liu 1,  Yi Jiang 3,  Chenglin Jiang 3,  Xueshi Huang 1
Affiliations

Affiliations

  • 1 Institute of Microbial Pharmaceuticals, College of Life and Health Sciences, Northeastern University , Shenyang 110819, People's Republic of China.
  • 2 Laboratory of Metabolic Disease Research and Drug Development, China Medical University , Shenyang 110001, People's Republic of China.
  • 3 Yunnan Institute of Microbiology, Yunnan University , Kunming 650091, People's Republic of China.
  • 4 Shanghai Institute of Pharmaceutical Industry , Shanghai 201203, People's Republic of China.
PMID: 28206772 DOI: 10.1021/acs.jnatprod.6b00676
Abstract

Six new fusicoccane-type Diterpenoids (2-7) were isolated from the fermentation broth of Streptomyces violascens, which was isolated from Ailuropoda melanoleuca (giant panda) feces. The structures of these new compounds were elucidated by a detailed spectroscopic data and X-ray crystallographic analysis. Compounds 5-7 demonstrated cytotoxicity against five human Cancer cell lines, with IC50 values ranging from 3.5 ± 0.7 to 14.1 ± 0.8 μM. Cell adhesion, migration, and invasion assays showed that 6 inhibited the migration and invasion of human hepatocellular carcinoma SMMC7721 cells in a dose-dependent manner. Through further investigation, it was revealed that 6 inhibited the enzymatic activity of matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9), in addition to down-regulating the expressions of MMP-2 and MMP-9 at both the protein and mRNA levels to influence the migration and invasion of Cancer cells.

Figures
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z