2. Academic Validation
  3. Novel molecules that antagonize leukotriene B4 binding to neutrophils

Novel molecules that antagonize leukotriene B4 binding to neutrophils

  • Ann N Y Acad Sci. 1988;524:196-200. doi: 10.1111/j.1749-6632.1988.tb38542.x.
A H Lin 1,  J Morris,  D G Wishka,  R R Gorman
Affiliations

Affiliation

  • 1 Cell Biology and Metabolic Diseases Research, Upjohn Company, Kalamazoo, Michigan 49001.
PMID: 2837955 DOI: 10.1111/j.1749-6632.1988.tb38542.x
Abstract

A series of LTB4 analogues have been synthesized that replace carbons 7-9 of the cis-trans-trans triene unit of LTB4 with a stable ring structure. Meta-substituted pyridine analogues are more potent inhibitors than benzene or furan analogues. C-1 alcohols are often more potent inhibitors than free carboxylic acids, and 5,6-cis double bond compounds are more potent than 5,6-trans compounds. Compounds such as these may prove to be useful in the treatment of inflammatory diseases.

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