1. Academic Validation
  2. Two new 14, 15-secopregnane-type steroidal glycosides from the roots of Cynanchum limprichtii

Two new 14, 15-secopregnane-type steroidal glycosides from the roots of Cynanchum limprichtii

  • Nat Prod Res. 2018 Feb;32(3):261-267. doi: 10.1080/14786419.2017.1353506.
Jia-Chuan Liu 1 2 3 Li-Li Yu 3 Shao-Fei Chen 1 2 Xiao-Jie Lu 1 2 Dan Zhao 1 2 Hai-Feng Wang 1 2 Gang Chen 1 2 Yue-Hu Pei 1 2
Affiliations

Affiliations

  • 1 a School of Traditional Chinese Materia Medica , Shenyang Pharmaceutical University , Shenyang , China.
  • 2 b Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education , Shenyang Pharmaceutical University , Shenyang , China.
  • 3 c College of Basic Science , Jinzhou Medical University , Jinzhou , China.
Abstract

Two new steroidal glycosides 1 and 2, along with three known ones (3-5), were isolated from the 95% ethanol extract of the roots of Cynanchum limprichtii Schltr. The structure of the new compounds was elucidated as 3-O-α-L-diginopyranosyl-(1→4)-β-D-digitoxopyranosyl-(1→4)-β-D-cymaropyranosyl-(1→4)-β-D-thevetopyranosyl-14, 16:15, 20:18, 20-triepoxy-14, 15-secopregn-4, 6, 8 (14)-triene (1) and 3-O-α-L-cymaropyranosyl-(1→4)-β-D-digitoxopyranosyl- (1→4)-β-D-3-demethyl-2-deoxythevetopyranosyl-14, 16: 15, 20: 8, 20-triepoxy-14, 15-secopregn-5, 8 (14)-diene (2) on the basis of spectroscopic analysis together with acidic hydrolysis. All compounds showed cytotoxic activity against the human Cancer cell line HL60, with IC50 values of 55.36, 65.41, 17.88, 17.68 and 33.5 μM, respectively. While, only compound 3 showed cytotoxicity against the Caco-2 cell line, with an IC50 value of 67.47 μM.

Keywords

Cynanchum limprichtii; cytotoxicity; steroidal glycoside.

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